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Since my residency I dealt with patients having complex diseasses, being undiagnosed for a long time, often years. I edged this interest in 2012 by embarging on a fellowship within the "Undiagnosed Diseases Program" at the National Institutes of Health, Bethesda/Washington, Maryland, USA. This is a clinical research program dedicated to patients form the US and other parts of the world suffering from undiagnosed diseases seeking to solve such constellations.